diff --git a/src/video_core/buffer_cache/buffer_cache.h b/src/video_core/buffer_cache/buffer_cache.h
index 95c67f865a..127a23637f 100644
--- a/src/video_core/buffer_cache/buffer_cache.h
+++ b/src/video_core/buffer_cache/buffer_cache.h
@@ -811,7 +811,7 @@ void BufferCache<P>::BindHostVertexBuffers() {
     if (use_optimized_vertex_buffers) {
         auto& flags = maxwell3d->dirty.flags;
         const u32 enabled_mask = enabled_vertex_buffers_mask;
-        bool any_dirty = false;
+        u32 dirty_mask = 0;
         u32 pending_mask = enabled_mask;
         while (pending_mask != 0) {
             const u32 index = std::countr_zero(pending_mask);
@@ -820,13 +820,15 @@ void BufferCache<P>::BindHostVertexBuffers() {
             Buffer& buffer = slot_buffers[binding.buffer_id];
             TouchBuffer(buffer, binding.buffer_id);
             SynchronizeBuffer(buffer, binding.device_addr, binding.size);
-            any_dirty |= flags[Dirty::VertexBuffer0 + index];
+            if (flags[Dirty::VertexBuffer0 + index]) {
+                dirty_mask |= 1u << index;
+            }
         }
-        if (enabled_mask == 0 || !any_dirty) {
+        if (dirty_mask == 0) {
             return;
         }
-        const u32 min_index = static_cast<u32>(std::countr_zero(enabled_mask));
-        const u32 max_index = 32u - static_cast<u32>(std::countl_zero(enabled_mask));
+        const u32 min_index = static_cast<u32>(std::countr_zero(dirty_mask));
+        const u32 max_index = 32u - static_cast<u32>(std::countl_zero(dirty_mask));
         HostBindings<Buffer> bindings{};
         bindings.min_index = min_index;
         bindings.max_index = max_index;
diff --git a/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp b/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp
index 29356cfcec..6c2ba89026 100644
--- a/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp
+++ b/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp
@@ -32,6 +32,7 @@ using Shader::Backend::SPIRV::RESCALING_LAYOUT_WORDS_OFFSET;
 using Tegra::Texture::TexturePair;
 
 ComputePipeline::ComputePipeline(const Device& device_, Scheduler& scheduler, vk::PipelineCache& pipeline_cache_,
+                                 std::shared_mutex& pipeline_cache_mutex_,
                                  DescriptorPool& descriptor_pool,
                                  GuestDescriptorQueue& guest_descriptor_queue_,
                                  DescriptorBufferRing& descriptor_buffer_ring_,
@@ -40,7 +41,8 @@ ComputePipeline::ComputePipeline(const Device& device_, Scheduler& scheduler, vk
                                  VideoCore::ShaderNotify* shader_notify, const Shader::Info& info_,
                                  vk::ShaderModule spv_module_, u64 shader_hash_)
     : device{device_},
-      pipeline_cache(pipeline_cache_), guest_descriptor_queue{guest_descriptor_queue_},
+      pipeline_cache(pipeline_cache_), pipeline_cache_mutex(pipeline_cache_mutex_),
+      guest_descriptor_queue{guest_descriptor_queue_},
       descriptor_buffer_ring{descriptor_buffer_ring_}, info{info_},
       shader_hash{shader_hash_}, spv_module(std::move(spv_module_)) {
     if (shader_notify) {
@@ -111,6 +113,7 @@ ComputePipeline::ComputePipeline(const Device& device_, Scheduler& scheduler, vk
             .basePipelineIndex = 0,
         };
         try {
+            std::shared_lock cache_lock{pipeline_cache_mutex};
             pipeline = device.GetLogical().CreateComputePipeline(compute_ci, *pipeline_cache);
         } catch (const vk::Exception& exception) {
             LOG_CRITICAL(Render_Vulkan, "Adreno rejected compute shader {:016X}: {}", shader_hash,
diff --git a/src/video_core/renderer_vulkan/vk_compute_pipeline.h b/src/video_core/renderer_vulkan/vk_compute_pipeline.h
index fba0519b58..65d4bb1382 100644
--- a/src/video_core/renderer_vulkan/vk_compute_pipeline.h
+++ b/src/video_core/renderer_vulkan/vk_compute_pipeline.h
@@ -9,6 +9,7 @@
 #include <atomic>
 #include <condition_variable>
 #include <mutex>
+#include <shared_mutex>
 
 #include "common/common_types.h"
 #include "common/thread_worker.h"
@@ -34,6 +35,7 @@ class Scheduler;
 class ComputePipeline {
 public:
     explicit ComputePipeline(const Device& device, Scheduler& scheduler, vk::PipelineCache& pipeline_cache,
+                             std::shared_mutex& pipeline_cache_mutex,
                              DescriptorPool& descriptor_pool,
                              GuestDescriptorQueue& guest_descriptor_queue,
                              DescriptorBufferRing& descriptor_buffer_ring,
@@ -59,6 +61,7 @@ public:
 private:
     const Device& device;
     vk::PipelineCache& pipeline_cache;
+    std::shared_mutex& pipeline_cache_mutex;
     GuestDescriptorQueue& guest_descriptor_queue;
     DescriptorBufferRing& descriptor_buffer_ring;
     Shader::Info info;
diff --git a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
index a2eee7f16d..554cc038ef 100644
--- a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
+++ b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
@@ -251,7 +251,8 @@ ConfigureFuncPtr ConfigureFunc(const std::array<vk::ShaderModule, NUM_STAGES>& m
 // TODO(crueter): This is the worst-formatted code I have EVER seen
 GraphicsPipeline::GraphicsPipeline(
     Scheduler& scheduler_, BufferCache& buffer_cache_, TextureCache& texture_cache_,
-    vk::PipelineCache& pipeline_cache_, VideoCore::ShaderNotify* shader_notify,
+    vk::PipelineCache& pipeline_cache_, std::shared_mutex& pipeline_cache_mutex_,
+    VideoCore::ShaderNotify* shader_notify,
     const Device& device_, DescriptorPool& descriptor_pool,
     GuestDescriptorQueue& guest_descriptor_queue_, DescriptorBufferRing& descriptor_buffer_ring_,
     Common::ThreadWorker* worker_thread,
@@ -259,7 +260,8 @@ GraphicsPipeline::GraphicsPipeline(
     const GraphicsPipelineCacheKey& key_, std::array<vk::ShaderModule, NUM_STAGES> stages,
     const std::array<const Shader::Info*, NUM_STAGES>& infos)
     : key{key_}, device{device_}, texture_cache{texture_cache_}, buffer_cache{buffer_cache_},
-      pipeline_cache(pipeline_cache_), scheduler{scheduler_},
+      pipeline_cache(pipeline_cache_), pipeline_cache_mutex(pipeline_cache_mutex_),
+      scheduler{scheduler_},
       guest_descriptor_queue{guest_descriptor_queue_},
       descriptor_buffer_ring{descriptor_buffer_ring_}, spv_modules{std::move(stages)} {
     if (shader_notify) {
@@ -1081,6 +1083,7 @@ void GraphicsPipeline::MakePipeline(VkRenderPass render_pass) {
         flags |= VK_PIPELINE_CREATE_DESCRIPTOR_BUFFER_BIT_EXT;
     }
 
+    std::shared_lock cache_lock{pipeline_cache_mutex};
     pipeline = device.GetLogical().CreateGraphicsPipeline({
         .sType = VK_STRUCTURE_TYPE_GRAPHICS_PIPELINE_CREATE_INFO,
         .pNext = nullptr,
diff --git a/src/video_core/renderer_vulkan/vk_graphics_pipeline.h b/src/video_core/renderer_vulkan/vk_graphics_pipeline.h
index b1ac5a3fcc..ebb92a8f16 100644
--- a/src/video_core/renderer_vulkan/vk_graphics_pipeline.h
+++ b/src/video_core/renderer_vulkan/vk_graphics_pipeline.h
@@ -11,6 +11,7 @@
 #include <atomic>
 #include <condition_variable>
 #include <mutex>
+#include <shared_mutex>
 #include <type_traits>
 #include <vector>
 
@@ -78,7 +79,8 @@ class GraphicsPipeline {
 public:
     explicit GraphicsPipeline(
         Scheduler& scheduler, BufferCache& buffer_cache, TextureCache& texture_cache,
-        vk::PipelineCache& pipeline_cache, VideoCore::ShaderNotify* shader_notify,
+        vk::PipelineCache& pipeline_cache, std::shared_mutex& pipeline_cache_mutex,
+        VideoCore::ShaderNotify* shader_notify,
         const Device& device, DescriptorPool& descriptor_pool,
         GuestDescriptorQueue& guest_descriptor_queue,
         DescriptorBufferRing& descriptor_buffer_ring, Common::ThreadWorker* worker_thread,
@@ -151,6 +153,7 @@ private:
     TextureCache& texture_cache;
     BufferCache& buffer_cache;
     vk::PipelineCache& pipeline_cache;
+    std::shared_mutex& pipeline_cache_mutex;
     Scheduler& scheduler;
     GuestDescriptorQueue& guest_descriptor_queue;
     DescriptorBufferRing& descriptor_buffer_ring;
diff --git a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
index 96007ec276..d1948fa59b 100644
--- a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
+++ b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
@@ -553,6 +553,7 @@ PipelineCache::PipelineCache(Tegra::MaxwellDeviceMemoryManager& device_memory_,
 
 PipelineCache::~PipelineCache() {
     if (use_vulkan_pipeline_cache && !vulkan_pipeline_cache_filename.empty()) {
+        std::unique_lock lock{vulkan_pipeline_cache_mutex};
         SerializeVulkanPipelineCache(vulkan_pipeline_cache_filename, vulkan_pipeline_cache,
                                      CACHE_VERSION);
     }
@@ -612,6 +613,7 @@ void PipelineCache::LoadDiskResources(u64 title_id, std::stop_token stop_loading
 
     if (use_vulkan_pipeline_cache) {
         vulkan_pipeline_cache_filename = base_dir / "vulkan_pipelines.bin";
+        std::unique_lock lock{vulkan_pipeline_cache_mutex};
         vulkan_pipeline_cache =
             LoadVulkanPipelineCache(vulkan_pipeline_cache_filename, CACHE_VERSION);
     }
@@ -710,6 +712,7 @@ void PipelineCache::LoadDiskResources(u64 title_id, std::stop_token stop_loading
     workers.WaitForRequests(stop_loading);
 
     if (use_vulkan_pipeline_cache) {
+        std::unique_lock lock{vulkan_pipeline_cache_mutex};
         SerializeVulkanPipelineCache(vulkan_pipeline_cache_filename, vulkan_pipeline_cache,
                                      CACHE_VERSION);
         size_t size = 0;
@@ -743,11 +746,14 @@ void PipelineCache::QueueVulkanPipelineCacheFlush() {
     pipelines_since_flush = 0;
     last_flush = now;
     serialization_thread.QueueWork([this] {
-        SerializeVulkanPipelineCache(vulkan_pipeline_cache_filename, vulkan_pipeline_cache,
-                                     CACHE_VERSION);
-        size_t size = 0;
-        vulkan_pipeline_cache.Read(&size, nullptr);
-        last_cache_size.store(size, std::memory_order_relaxed);
+        {
+            std::unique_lock lock{vulkan_pipeline_cache_mutex};
+            SerializeVulkanPipelineCache(vulkan_pipeline_cache_filename, vulkan_pipeline_cache,
+                                         CACHE_VERSION);
+            size_t size = 0;
+            vulkan_pipeline_cache.Read(&size, nullptr);
+            last_cache_size.store(size, std::memory_order_relaxed);
+        }
         flush_in_flight.store(false, std::memory_order_release);
     });
 }
@@ -890,7 +896,8 @@ std::unique_ptr<GraphicsPipeline> PipelineCache::CreateGraphicsPipeline(
     }
     Common::ThreadWorker* const thread_worker{build_in_parallel ? &workers : nullptr};
     return std::make_unique<GraphicsPipeline>(
-        scheduler, buffer_cache, texture_cache, vulkan_pipeline_cache, &shader_notify, device,
+        scheduler, buffer_cache, texture_cache, vulkan_pipeline_cache,
+        vulkan_pipeline_cache_mutex, &shader_notify, device,
         descriptor_pool, guest_descriptor_queue, descriptor_buffer_ring, thread_worker, statistics,
         render_pass_cache, key, std::move(modules), infos);
 
@@ -1014,7 +1021,8 @@ std::unique_ptr<ComputePipeline> PipelineCache::CreateComputePipeline(
         spv_module.SetObjectNameEXT(name.c_str());
     }
     Common::ThreadWorker* const thread_worker{build_in_parallel ? &workers : nullptr};
-    return std::make_unique<ComputePipeline>(device, scheduler, vulkan_pipeline_cache, descriptor_pool,
+    return std::make_unique<ComputePipeline>(device, scheduler, vulkan_pipeline_cache,
+                                             vulkan_pipeline_cache_mutex, descriptor_pool,
                                              guest_descriptor_queue, descriptor_buffer_ring,
                                              thread_worker, statistics,
                                              &shader_notify, program.info, std::move(spv_module),
diff --git a/src/video_core/renderer_vulkan/vk_pipeline_cache.h b/src/video_core/renderer_vulkan/vk_pipeline_cache.h
index 9d66b663f5..94cf733890 100644
--- a/src/video_core/renderer_vulkan/vk_pipeline_cache.h
+++ b/src/video_core/renderer_vulkan/vk_pipeline_cache.h
@@ -12,6 +12,8 @@
 #include <cstddef>
 #include <filesystem>
 #include <memory>
+#include <mutex>
+#include <shared_mutex>
 #include <type_traits>
 #include <ankerl/unordered_dense.h>
 #include <vector>
@@ -175,6 +177,7 @@ private:
 
     std::filesystem::path vulkan_pipeline_cache_filename;
     vk::PipelineCache vulkan_pipeline_cache;
+    std::shared_mutex vulkan_pipeline_cache_mutex;
     size_t pipelines_since_flush{};
     std::chrono::steady_clock::time_point last_flush{};
     std::atomic<size_t> last_cache_size{};