diff --git a/src/video_core/renderer_opengl/gl_shader_cache.cpp b/src/video_core/renderer_opengl/gl_shader_cache.cpp
index df69eb97f5..277cf222fa 100644
--- a/src/video_core/renderer_opengl/gl_shader_cache.cpp
+++ b/src/video_core/renderer_opengl/gl_shader_cache.cpp
@@ -414,6 +414,11 @@ GraphicsPipeline* ShaderCache::BuiltPipeline(GraphicsPipeline* pipeline) const n
     if (!use_asynchronous_shaders) {
         return pipeline;
     }
+    // If something is using depth, we can assume that games are not rendering anything which
+    // will be used one time.
+    if (maxwell3d->regs.zeta_enable) {
+        return nullptr;
+    }
     // If games are using a small index count, we can assume these are full screen quads.
     // Usually these shaders are only used once for building textures so we can assume they
     // can't be built async
diff --git a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
index a85e2811a3..632c3d6a0f 100644
--- a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
+++ b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
@@ -787,6 +787,11 @@ GraphicsPipeline* PipelineCache::BuiltPipeline(GraphicsPipeline* pipeline) const
     if (!use_asynchronous_shaders) {
         return pipeline;
     }
+    // If something is using depth, we can assume that games are not rendering anything which
+    // will be used one time.
+    if (maxwell3d->regs.zeta_enable) {
+        return nullptr;
+    }
     // If games are using a small index count, we can assume these are full screen quads.
     // Usually these shaders are only used once for building textures so we can assume they
     // can't be built async